Sulfasalazine decreases soluble fms-like tyrosine kinase-1 secretion potentially via inhibition of upstream placental epidermal growth factor receptor signalling

R Hastie; FC Brownfoot; P Cannon; V Nguyen; L Tuohey; NJ Hannan; S Tong; TJ Kaitu'u-Lino

Journal article

Sulfasalazine decreases soluble fms-like tyrosine kinase-1 secretion potentially via inhibition of upstream placental epidermal growth factor receptor signalling

R Hastie, FC Brownfoot, P Cannon, V Nguyen, L Tuohey, NJ Hannan, S Tong, TJ Kaitu'u-Lino

Placenta | W B SAUNDERS CO LTD | Published : 2019

DOI: 10.1016/j.placenta.2019.09.004

Abstract

Objectives: Preeclampsia is a hypertensive disorder of pregnancy with no available medical treatment. We recently reported sulfasalazine, an anti-inflammatory medication, to be a candidate therapeutic for preeclampsia. We showed sulfasalazine decreases placental secretion of soluble Fms-like tyrosine kinase-1 (sFlt-1), an anti-angiogenic factor strongly implicated in the pathogenesis of preeclampsia. However, the cellular mechanism(s) by which sulfasalazine reduces placental sFlt-1 are yet to be determined. Recently we also reported that both the mitochondria and the epidermal growth factor receptor (EGFR) signalling pathways regulate secretion of placental sFlt-1. In this study we sought to..

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University of Melbourne Researchers

Roxanne Hastie Author

Fiona Brownfoot Author

Ping Cannon Author

Vi Nguyen Author

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Grants

Funding Acknowledgements

Tong (#1136418), T.J. Kaitu'u-Lino (#1159261), N.J. Hannan (#1146128) and F. Brownfoot (#1142636) were supported by NHMRC Fellowships. The funders had no role in study design, data collection, analysis, decision to publish or the preparation of the manuscript.